Cruziohyla is a genus of tree frogs in the Hylidae family. They are found in Nicaragua in Central America south to the Amazon Basin in South America. This genus was erected in 2005 following a major revision of the Hylidae family. The two species in this genus were previously placed in the Agalychnis or Phyllomedusa genera.

These frogs are characterized by extensive hand and foot webbing. Their eye has a bicoloured iris. Tadpoles develop in water-filled depressions on fallen trees.

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