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The Caspian cobra (Naja oxiana), also called the Central Asian cobraOxus cobraor Russian cobra, a member of the family Elapidae found in Central Asia.

This species is medium to large in length, a heavy-bodied snake with long cervical ribs capable of expansion to form a hood. The body is compressed dorsoventrally and subcylindrical posteriorly. This species averages about 1 m (3.3 ft) in length and rarely reaches lengths over 1.5 m (4.9 ft). The head is elliptical, depressed, and slightly distinct from the neck, with a short, rounded snout and large nostrils. The eyes are medium in size with round pupils. Dorsal scales are smooth and strongly oblique, with the outer two or three scale rows larger than the remainder. Juveniles tend to be pale, with a faded appearance. They have noticeable dark and light cross-bands of approximately equal width around the body. Adults of this species are completely light to chocolate brown or yellowish, some retain traces of juvenile banding, especially the first few dark ventral bands. This species has no hood mark and no lateral throat spots.

This species occurs in the Transcaspian region. It is found in Turkmenistan, Uzbekistan, Kyrgyzstan, Tadzhikistan, north and east Afghanistan, northeastern Iran, the northern half of Pakistan, from the Kashmir region east to the state of Himachal Pradesh in India, and in southwestern Tajikistan.

This species is often found in arid and semiarid, rocky or stony, shrub or scrub covered foothills at elevations up to about 3,000 m (9,800 ft) above sea level. This is also the westernmost species of Asiatic cobra.

This species is generally aggressive and bad-tempered. Although they will avoid humans as much as they can, they will become fiercely aggressive when threatened or cornered. Even juveniles tend to be very aggressive. When cornered and provoked, it will spread its hood, hiss, sway from side to side and strike repeatedly; it is not a spitter. This terrestrial species is mainly diurnal, but it may be crepuscular and nocturnal in some parts of its range during the hottest months (July and August). It is a good climber and a good swimmer. It is often found in water and seldom found too far away from it. It feeds on small mammals, amphibians and birds during the evening and early morning. The Caspian cobra will prey mainly on rodents, toads and frogs, occasionally fish, birds and their eggs. Quick-moving and agile, this species lives in holes in embankments or trees.

The Caspian cobra is the most venomous species of cobra in the world, slightly ahead of the Philippine cobra, based on a 1992 toxicological study reported in the Indian Journal of Experimental Biology. A number of small non-enzymatic proteins are found in the venom, including neurotoxins and members of the cytotoxin family, which have been shown to cause cell death through damage to lysosomes.

In addition to nonenzymatic proteins, the venom also contains nucleases, which cause tissue damage at the site of the bite and may also potentiate systemic toxicity by releasing free purines in situ. A ribonuclease isolated and purified from Caspian cobra venom, ribonuclease V1, is commonly used as a laboratory reagent in molecular biology experiments due to its unusual ability to break down structured RNA.

The crude venom of this species has a lowest published lethal dose (LCLo) of 0.005 mg/kg, the lowest among all cobra species, derived from an individual case of poisoning by intracerebroventricular injection. Values for subcutaneous injection average 0.18 mg/kg (range 0.1 mg/kg - 0.26 mg/kg).

The murine subcutaneous LD50 value has been estimated between 0.21 mg/kg and 0.4 mg/kg. The intravenous injection route yielded estimates between 0.037 mg/kg and 0.078 mg/kg. Average venom yield per bite for this species is between 75 and 125 mg (dry weight), but can reach up to 590 mg.

The bite of this species may cause severe pain and swelling, along with severe neurotoxicity. Weakness, drowsiness, ataxia, hypotension, and paralysis of throat and limbs may appear in less than one hour after the bite. Without medical treatment, symptoms rapidly worsen and death can occur soon after a bite due to respiratory failure. A woman bitten by this species in northwestern Pakistan suffered severe neurotoxicity and died while en route to the closest hospital nearly 50 minutes after envenomation. Between 1979 and 1987, 136 confirmed bites were attributed to this species in the former Soviet Union. Of the 136, 121 received antivenom, and only four died. Of the 15 who did not receive antivenom, 11 died - a 73% mortality rate. Anti-venom is not as effective for envenomation by this species as it is for other Asiatic cobras within the same region, like the Indian cobra (Naja naja), and massive amounts of antivenom are often required for patients. As a result, a monovalent antivenom serum is being developed by the Razi Serum and Vaccine Research Institute in Iran. The untreated mortality rate for this species is approximately 70-75%, which is among the highest of all cobra species of the genus Naja. In both Central Asia and Iran this species is responsible for high rates of snakebites and resulting mortality.

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